منابع مشابه
Eplerenone: cardiovascular protection.
Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor-dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific aldosterone receptor antagonist, spironolactone, ...
متن کاملEplerenone ethanol solvate
EPLERENONE [SYSTEMATIC NAME: 7α-(methoxy-carbon-yl)-3-oxo-9α,11-ep-oxy-17α-pregn-4-ene-21,17-carbolactone], an aldo-sterone receptor antagonist, crystallizes from ethanol as a monosolvate, C(24)H(30)O(6)·C(2)H(6)O. The eplerenone mol-ecule has two five-membered rings, three six-membered rings and one three-membered ring. Both five-membered rings display envelope conformations, while the three s...
متن کاملEplerenone Final RGB
• Monographs for unlicensed drugs/indications must not be circulated to prescribers. • Not to be used for commercial purposes. • The information contained herein will be superseded in due course. • Copyright UKMIPG 2002. Date Published:December 2003 Monograph Number:3/03/05 Region of Origin to whom queries should be directed:West Midlands/National Prescribing Centre NEW DRUGS IN CLINICAL DEVELO...
متن کاملEplerenone use in primary aldosteronism during pregnancy
Primary aldosteronism (PA) in pregnancy is rare. Due to pharmacological limitations and risks associated with surgical intervention during pregnancy, clinical decision making in this area is difficult. We report the short-term use of eplerenone in the management of hypertension and hypokalemia due to PA in pregnancy.
متن کاملEplerenone inhibits atherosclerosis in nonhuman primates.
Aldosterone may be involved in the pathogenesis of atherosclerosis. We investigated the effect of eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis in monkeys fed a high-cholesterol diet. Monkeys fed a high-cholesterol diet for 9 months were divided into 3 groups: those treated with a low dose of eplerenone (30 mg/kg per day); those treated with a high dose of epler...
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ژورنال
عنوان ژورنال: Circulation
سال: 2003
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000071081.35693.9a